Inorganic, Bioinorganic & Biophysical Chemistry
Johns Hopkins University
3400 North Charles St.
Baltimore, MD 21218
PhD - University of Washington
NIH Post Doctoral Fellow - UC, Berkeley
The Roth group conducts research relevant to health, energy and the environment.
Radical Enzymes: Enzymes catalyze oxidative processes vital to life using transition metal ions found naturally in minerals and used in advanced materials as well as industrial processes. Proteins that act as enzymes, mediate coupled redox (often proton and electron transfer) reactions essential to life. These redox reactions are often coupled to gaseous reductions (respiration) in mammals and photosynthetic reactions in plants. We study naturally occurring molecules at the chemical and biological interface.
Heavy Atom Isotope Effects: Transition metals interact with small molecules such as CO2, N2, CO, NO and O2, in a range of physiological processes. Because of their relatively low molecular weights and the presence of natural occurring stable isotopes, 18O, 15N and 13C can be studied using highly precise isotope ratio mass spectrometry (IRMS) techniques. Currently, we are developing combined experimental and computational methods to investigate reactions that consume and produce O2. Natural and synthetic photocatalysts are being targeted to inform “water-splitting” efforts.
1. R. Sarma, A. M. Angeles-Boza, D. W. Brinkley, J. P. Roth* “Studies of the Di-Iron(VI) Intermediate in Ferrate-Dependent Oxygen Evolution from Water.” J. Am. Chem. Soc. 2012, 134, 15371-15286.
2. H. H. Danish, I. S. Doncheva, J. P. Roth* “Hydrogen Tunneling Steps in Cyclooxygenase-2 Catalysis.” J. Am. Chem. Soc. 2011, 133, 15846-15849.
3. A. Mukherjee, A. M. Angeles-Boza, G. S. Huff, D. W. Brinkley, J. P. Roth* “Catalytic Mechanism of a Heme and Tyrosyl Radical-Containing Fatty Acid α-(Di)oxygenase.” J. Am. Chem. Soc. 2011, 33, 227-238.
4. J. P. Roth* Oxygen Isotope Effects as Probes of Electron Transfer Mechanisms and Structures of Activated O2.” Acc. Chem. Res. 2009, 42, 399-408.